CD273 (B7-DC) Rat anti-Mouse, FITC, Clone: 122, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-9972-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15248399

Quantity Price
1 £ 72.77 / 50µg
EU Stock 3
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Description and Specification

Specification

Applications Flow Cytometry
Antigen CD273 (B7-DC)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Concentration 0.5mg/mL
Gene Alias PD-L2
Primary or Secondary Primary
Quantity 50μg
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone 122
Isotype IgG2a
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Conjugate FITC
Host Species Rat
Regulatory Status RUO

The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a member of the B7 family, has a predicted molecular weight of approximately 25kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25 (Cat. No.14-5986), another mAb specific for mouse B7-DC.