CD273 (B7-DC) Rat anti-Mouse, Clone: TY25, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5986-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15238727

Quantity Price
1 £ 78.88 / 50µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Isotype IgG2a
Clone TY25
Applications Flow Cytometry
Applications Functional Assay
Species Reactivity Mouse
Primary or Secondary Primary
Conjugate Unlabeled
Quantity 50μg
Monoclonal or Polyclonal Monoclonal
Concentration 1mg/mL
Format Purified
Host Species Rat
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Antigen CD273 (B7-DC)
Formulation aqueous buffer, no sodium azide
Gene Alias B7DC, PD-L2, PDL-2, PDL2

The TY25 monoclonal antibody reacts with mouse B7-DC/PD-L2. B7-DC, a member of the B7 family, has a predicted molecular weight of ∽25kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse.