CD273 (B7-DC) Rat anti-Mouse, Clone: TY25, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5986-81

Product Code. 15247667

Disclaimers:

For Research Use Only.

Description

The TY25 monoclonal antibody reacts with mouse B7-DC/PD-L2. B7-DC, a member of the B7 family, has a predicted molecular weight of ∽25kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse.

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Specifications

• Antigen: CD273 (B7-DC)
• Clone: TY25
• Conjugate: Unlabeled
• Format: Purified
• Host Species: Rat
• Quantity: 50μg
• Storage Requirements: Store at 2-8°C.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Western Blot
• Concentration: 0.5mg/mL
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Gene Alias: B7DC, PD-L2, PDL-2, PDL2
• Isotype: IgG2a
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Murine