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CD273 (B7-DC) Rat anti-Mouse, Clone: 122, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9972-81

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258297

  • £66.65 / 50µg


Estimated Shipment
01-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25 (Cat. No.14-5986), another mAb specific for mouse B7-DC.
Description & Specifications

Specifications

CD273 (B7-DC)
122
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
50μg
Store at 2-8°C.
Monoclonal
Flow Cytometry
0.5mg/mL
Purified
PD-L2
IgG2a
RUO
Primary
Murine