CD273 (B7-DC) Mouse anti-Human, PE, Clone: MIH18, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5888-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15537046

Quantity Price
1 £ 152.25 / 100 tests
EU Stock 4
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Description and Specification

Specification

Quantity 100 Tests
Host Species Murine
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone MIH18
Isotype IgG1
Regulatory Status RUO
Format Conjugated
Species Reactivity Human
Concentration 5μL (0.125μg)/test
Primary or Secondary Primary
Applications Flow Cytometry
Antigen CD273 (B7-DC)
Conjugate PE
Gene Alias PD-L2
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal

The MIH18 monoclonal antibody reacts with human B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25kDa and belongs to the Ig superfamily. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. MIH18 is a useful tool for studies to elucidate the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in humans. MIH18 is a blocking antibody.