CD273 (B7-DC) Mouse anti-Human, APC, Clone: MIH18, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5888-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15528156

Quantity Price
1 £ 182.82 / 100 tests
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Concentration 5μL (0.125μg)/test
Isotype IgG1
Gene Alias PD-L2 B7-DC
Primary or Secondary Primary
Host Species Mouse
Quantity 100 tests
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen CD273 (B7-DC)
Monoclonal or Polyclonal Monoclonal
Clone MIH18
Regulatory Status RUO
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate APC
Species Reactivity Human

The MIH18 monoclonal antibody reacts with human CD273, also known as PD-L2 or B7-DC, a member of the B7 family that has a predicted molecular weight of approximately 25 kDa, and belongs to the Ig superfamily. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. MIH18 is a useful tool for studies to elucidate the exact function of B7-DC/PD-L2 in APC/T cell interaction, and to characterize the expression pattern of this molecule in humans. MIH18 is a blocking antibody.