CD273 (B7-DC) Mouse anti-Human, APC, Clone: MIH18, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5888-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15518156

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD273 (B7-DC)
Gene Alias PD-L2 B7-DC
Species Reactivity Human
Regulatory Status RUO
Clone MIH18
Concentration 5μL (0.125μg)/test
Format Conjugated
Isotype IgG1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 25 tests
Applications Flow Cytometry
Conjugate APC
Primary or Secondary Primary
Host Species Mouse
Monoclonal or Polyclonal Monoclonal

The MIH18 monoclonal antibody reacts with human CD273, also known as PD-L2 or B7-DC, a member of the B7 family that has a predicted molecular weight of approximately 25 kDa, and belongs to the Ig superfamily. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. MIH18 is a useful tool for studies to elucidate the exact function of B7-DC/PD-L2 in APC/T cell interaction, and to characterize the expression pattern of this molecule in humans. MIH18 is a blocking antibody.