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CD272 (BTLA) Mouse anti-Mouse, APC, Clone: 8F4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5956-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.00001kg

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Product Code. 15330800

  • £188.93 / 100µg


Estimated Shipment
02-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The BTLA antibody reacts with mouse BTLA, B and T lymphocyte attenuator from both BALB/c and C57Bl/6 strains. BTLA is expressed by peripheral lymphocytes, splenic macrophages, developing B cells in the bone marrow and developing T cells in thymus and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. It is reported that BTLA binds to B7-H4, but further studies are needed to confirm this interaction.

Note: The anti-mouse BTLA monoclonal antibody 6F7 is reported to stain CD4+ and CD8+ single-positive (SP) thymocytes (Hurchla et al). However, other anti-mouse BTLA clones generated simultaneously with 6F7 (8F4, 3F9.D12, 6G3 and 6H6) do not stain SP thymocytes . It is not understood why there is a discrepancy in thymocyte staining. However, in staining of splenocytes and bone marrow cells, clones 8F4, 3F9.D12, 6G3 and 6H6 stain similar populations to 6F7.
Specifications

Specifications

CD272 (BTLA)
8F4
Allophycocyanin
Conjugated
Murine
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
B and T lymphocyte attenuator
IgG1
RUO
Primary
Murine