CD270 (HVEM) Armenian Hamster anti-Mouse, Clone: LH1, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5962-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15207637

Quantity Price
1 £ 152.25 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG
Storage Requirements Store at 2-8°C.
Antigen CD270 (HVEM)
Applications Flow Cytometry
Applications Functional Assay
Conjugate Unlabeled
Gene Alias herpes virus entry mediator, TNFRSF14, LIGHTR
Quantity 100μg
Clone LH1
Species Reactivity Mouse
Format Purified
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Primary or Secondary Primary
Host Species Armenian Hamster
Concentration 0.5mg/mL

The LH1 monoclonal antibody reacts with mouse Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is found on most cell types, including T cells, B cells, monocytes, neutrophils and dendritic cells. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of HVEM was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. HVEM has also been demonstrated to be a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response. The LH1 antibody has been reported as a blocking antibody, interfering with the HVEM-LIGHT interaction but not the HVEM-BTLA interaction.