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CD266 (TWEAK Receptor) Mouse anti-Human, Mouse, Biotin, Clone: ITEM-4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-9018-82

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15340090

  • £164.47 / 100µg


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For Research Use Only.


Description

Description

The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.
The ITEM-4 antibody has been show to have blocking function.
Specifications

Specifications

CD266 (TWEAK Receptor)
ITEM-4
Biotin
Conjugated
Murine
100μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
IgG2b
RUO
Primary
Murine
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