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CD266 (TWEAK Receptor) Mouse anti-Human, Clone: ITEM-1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9019-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258127

  • £140.02 / 100µg


Estimated Shipment
07-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.
Description & Specifications

Specifications

CD266 (TWEAK Receptor)
ITEM-1
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal
Immunohistochemistry (Frozen)
0.5mg/mL
Purified
TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
IgG1
RUO
Primary
Human