CD266 (TWEAK Receptor) Mouse anti-Human, Clone: ITEM-1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9019-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258127

Quantity Price
1 £ 140.02 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Species Reactivity Human
Concentration 0.5mg/mL
Storage Requirements Store at 2-8°C.
Gene Alias TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Isotype IgG1
Clone ITEM-1
Antigen CD266 (TWEAK Receptor)
Quantity 100μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Conjugate Unlabeled
Format Purified

The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.