missing translation for 'onlineSavingsMsg'
Learn More

CD266 (TWEAK Receptor) Mouse anti-Human, Clone: ITEM-1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9019-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15248127

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Product Support team on 01509 555888 for assistance
View alternative products »

Disclaimers:

For Research Use Only.


Description

Description

The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.
Specifications

Specifications

CD266 (TWEAK Receptor)
ITEM-1
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Immunohistochemistry (Frozen)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
IgG1
RUO
Primary
Human