CD266 (TWEAK Receptor), clone: ITEM-1, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9019-80
Code : Z2
Additional Details : Weight : 0.01000kg
DescriptionThe ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.
|CD266 (TWEAK Receptor)|
|Store at 2-8°C.|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14|
For Research Use Only.