CD265 (RANK) Rat anti-Mouse, Clone: R12-31, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6612-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15207927

Quantity Price
1 £ 115.56 / 100µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Species Reactivity Mouse
Quantity 100μg
Antigen CD265 (RANK)
Applications Flow Cytometry
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Format Purified
Isotype IgG2a
Primary or Secondary Primary
Concentration 0.5mg/mL
Host Species Rat
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Gene Alias Receptor Activator of NF-kB
Clone R12-31

The R12-31 monoclonal antibody reacts with mouse RANK (Receptor activator of NF-κB), a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-κB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-κB, whereas JNK activation is mediated through binding of RANK to TRAF2.