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CD265 (RANK) Rat anti-Mouse, Biotin, Clone: R12-31, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-6612-81

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15370000

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Disclaimers:

For Research Use Only.


Description

Description

The R12-31 monoclonal antibody reacts with mouse RANK (Receptor activator of NF-κB), a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-κB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-κB, whereas JNK activation is mediated through binding of RANK to TRAF2.
Specifications

Specifications

CD265 (RANK)
R12-31
Biotin
Conjugated
Rat
50μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Receptor Activator of NF-kB
IgG2a
RUO
Primary
Murine
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