CD265 (RANK) Rat anti-Mouse, Biotin, Clone: R12-31, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-6612-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15380000

Quantity Price
1 £ 127.8 / 100µg
Estimated Shipment date
from Supplier 09-05-2017
Add to basket


Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD265 (RANK)
Isotype IgG2a
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze.
Concentration 0.5mg/mL
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Gene Alias Receptor Activator of NF-kB
Host Species Rat
Quantity 100μg
Format Conjugated
Clone R12-31
Conjugate Biotin
Primary or Secondary Primary

The R12-31 monoclonal antibody reacts with mouse RANK (Receptor activator of NF-κB), a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-κB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-κB, whereas JNK activation is mediated through binding of RANK to TRAF2.