CD26 Rat anti-Mouse, PerCP-Cy5.5, Clone: H194-112 (H194-112.12.4.4.5), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 45-0261-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15381150

Quantity Price
1 £ 182.82 / 100µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Antigen CD26
Conjugate PerCP-Cy5.5
Isotype IgG2a
Regulatory Status RUO
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL
Species Reactivity Mouse
Clone H194-112 (H194-112.12.4.4.5)
Monoclonal or Polyclonal Monoclonal
Gene Alias Dipeptidyl Peptidase IV, DPPIV, DPP4,
Host Species Rat
Primary or Secondary Primary
Quantity 100μg
Applications Flow Cytometry

The monoclonal antibody H194-112 recognizes mouse CD26, a thymocyte-activating molecule (THAM). CD26 is a surface expressed and soluble ectoenzyme (dipeptidyl peptidase IV) that cleaves dipeptides from the amino terminus of proteins. In particular CD26 has been shown to cleave CXCL12, CCL22, neuropeptide Y and glucagon. CD26 is involved in adhesion, apoptosis, disease regulation, and engraftment. Expression is regulated during thymic development at the messenger RNA level. Additionally, CD26 protein is found on thymocytes, a percentage of resting B cells, stimulated B cells, NK cells and a percentage of resting and activated T cells and other epithelial cell types. On human cells more CD26 protein is found on Th2 cells. Functional CD26 is expressed on Sca-1+c-Kit+lin- cells. This expression has been shown to correlate with mobilization of progenitor cells. Inhibition of CD26 activity through a variety of compounds enhances allogenic stem cell homing and engraftment.

This antibody is reported to have activating function.