CD258 (LIGHT) Mouse anti-Human, APC, Clone: 7-3 (7), eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 17-2589-41
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionApoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
|PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2|
|TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; CD258; HVEML; LIGHT; LTg; TR2; delta transmembrane LIGHT; herpesvirus entry mediator A; ligand for herpesvirus entry mediator; tumor necrosis factor ligand superfamily, member 14; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.