CD257 (BAFF, BLyS) Mouse anti-Human, FITC, Clone: 1D6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-9017-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586606

Quantity Price
1 £ 170.59 / 100 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Primary or Secondary Primary
Isotype IgG1
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Concentration 5μL (0.5μg)/test
Antigen CD257 (BAFF, BLyS)
Gene Alias TNFSF13B, BLYS, TALL-1, TALL1, THANK
Quantity 100 tests
Conjugate FITC
Species Reactivity Human
Format Conjugated
Clone 1D6
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The 1D6 monoclonal antibody reacts with human BLyS (B lymphocyte stimulator), also known as BAFF (B cell activating factor from the TNF family), TALL-1 (TNF and apoptosis leukocyte-expressed ligand-1), THANK (TNF homologue that activates apoptosis, nuclear factor KappaB and c-Jun NH2-terminal kinase) and zTNF4. BLyS, a member of the TNF family, is a type II membrane protein that exists in both membrane-bound and soluble forms. Expression of membrane-bound BLyS on monocytes lineage is regulated by IFN-γ. BLyS acts as a potent B cell growth factor and costimulator of Ig production. BLyS transgenic mice develop severe B cell hyperplasia and autoimmune lupus-like disease characterized by the presence of autoantibodies against nuclear antigens and immune complexes deposited in the kidney. Data from animal models imply a role for BLyS in human autoimmune diseases. To date BCMA, TACI and BR3 have been identified as receptors for BLyS. APRIL, another TNF family member, and BLyS can form active heterotrimeric molecules when coexpressed and these circulating heterotrimers are present in serum samples from patients with systemic immune-based rheumatic diseases. Furthermore, it has been reported that BLyS and APRIL, share BCMA and TACI as their receptors.