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CD254 (RANK Ligand) Rat anti-Mouse, Clone: IK22/5, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5952-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15227627

  • £152.25 / 100µg


Estimated Shipment
02-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The IK22/5 monoclonal antibody reacts with mouse CD254 also known as TRANCE (TNF-related activation-induced cytokine receptor) and RANKL (receptor activator of NF-kappa B ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation and is expressed abundantly by mouse T cells not B cells in mouse thymus and lymph nodes. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.
Description & Specifications

Specifications

CD254 (RANK Ligand)
IK22/5
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
100μg
Store at 2-8°C.
Monoclonal
Functional Assay
0.5mg/mL
Purified
OPGL, TNFSF11, ODF
IgG2a
RUO
Primary
Murine