CD254 (RANK Ligand) Rat anti-Mouse, Biotin, Clone: IK22/5, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-5952-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15229949

Quantity Price
1 £ 158.36 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Species Reactivity Mouse
Antigen CD254 (RANK Ligand)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG2a
Clone IK22/5
Conjugate Biotin
Concentration 0.5mg/mL
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Applications Flow Cytometry
Quantity 100μg
Host Species Rat
Primary or Secondary Primary
Gene Alias OPGL, TNFSF11, ODF
Storage Requirements Store at 2-8°C. Do not freeze.

The IK22/5 monoclonal antibody reacts with mouse CD254 also known as TRANCE (TNF-related activation-induced cytokine receptor) and RANKL (receptor activator of NF-kappa B ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation and is expressed abundantly by mouse T cells not B cells in mouse thymus and lymph nodes. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.