CD254 (RANK Ligand) Mouse anti-Human, PE, Clone: MIH24, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-6619-80

25UG ANTI-HUMAN CD254 (RANK LIGAND) PE

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15239259

Quantity Price
1 £ 91.11 / 25µg
Estimated Shipment date
from Supplier 29-03-2017
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Description and Specification

Specification

Host Species Mouse
Isotype IgG2b
Quantity 25μg
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Clone MIH24
Antigen CD254 (RANK Ligand)
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias TRANCE, OPGL, RANKL
Applications Flow Cytometry
Regulatory Status RUO
Primary or Secondary Primary
Concentration 0.2mg/mL
Conjugate PE

The MIH24 monoclonal antibody reacts with human TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-κB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.