CD254 (RANK Ligand) Mouse anti-Human, Clone: MIH24, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6619-82

Product Code. 15237927

Disclaimers:

For Research Use Only.

Description

The MIH24 monoclonal antibody reacts with human TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-κB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-x_L.

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Specifications

• Antigen: CD254 (RANK Ligand)
• Clone: MIH24
• Conjugate: Unlabeled
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Host Species: Murine
• Quantity: 100μg
• Storage Requirements: Store at 2-8°C.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Concentration: 0.5mg/mL
• Format: Purified
• Gene Alias: TRANCE, OPGL, RANKL
• Isotype: IgG2b
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human