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CD254 (RANK Ligand) Mouse anti-Human, Clone: MIH24, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6619-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15237927

  • £158.36 / 100µg


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For Research Use Only.


Description

Description

The MIH24 monoclonal antibody reacts with human TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-κB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.
Specifications

Specifications

CD254 (RANK Ligand)
MIH24
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TRANCE, OPGL, RANKL
IgG2b
RUO
Primary
Human