CD254 (RANK Ligand) Mouse anti-Human, Clone: MIH24, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6619-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227927

Quantity Price
1 £ 72.77 / 25µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Isotype IgG2b
Quantity 25μg
Regulatory Status RUO
Gene Alias TRANCE, OPGL, RANKL
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Concentration 0.5mg/mL
Clone MIH24
Format Purified
Species Reactivity Human
Host Species Mouse
Applications ELISA Detection
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C.
Antigen CD254 (RANK Ligand)

The MIH24 monoclonal antibody reacts with human TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-κB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.