CD25 Rat anti-Mouse, Clone: PC61.5, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0251-86

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15276867

Quantity Price
1 £ 195.05 / 1mg
EU Stock 6
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Description and Specification

Specification

Host Species Rat
Species Reactivity Mouse
Primary or Secondary Primary
Isotype IgG1
Gene Alias Interleukin-2 Receptor alpha
Conjugate Unlabeled
Antigen CD25
Concentration 0.5mg/mL
Applications Flow Cytometry
Clone PC61.5
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Purified
Regulatory Status RUO
Quantity 1mg
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.

The PC61.5 antibody reacts with mouse CD25, the 55kDa interleukin-2 receptor alpha chain (IL-2R alpha). CD25 is expressed by early progenitors of the T and B lineage as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 only with low affinity. However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. Binding of IL-2 to both the high and low affinity classes of IL-2 receptor is inhibited by the PC61.5 antibody. CD25 plays a role in lymphocyte differentiation and activation/proliferation.