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CD25 Mouse anti-Human, Clone: GLLZDMY, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0256-80

Code : NEW

Additional Details : Weight : 0.09500kg

Product Code. 15567416

  • £45.15 / 25µg

Estimated Shipment date
from Supplier 30-03-2020

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Description

Description

CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Specifications

Specifications

CD25
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P01589
IL2 RA antibody, Il2ra antibody, Interleukin 2 receptor alpha chain antibody, TAC antigen antibody, IL-2R alpha chain
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
GLLZDMY
Unconjugated
IL2RA
Liquid
IL2RA
IgG1, kappa
25 μg
4° C
Primary
3559
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For Research Use Only.