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CD244 Mouse anti-Human, Biotin, Clone: eBioC1.7 (C1.7), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-5838-82

Code : Z2

Additional Details : Weight : 0.25000kg

 View more versions of this product

Product Code. 15299869

  • £72.77 / 100µg


Estimated Shipment date
from Supplier 23-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The eBioC1.7 monoclonal antibody reacts with human CD244 (2B4, p38). In human, CD244 is a 38kDa protein expressed on NK cells, a subset of CD8+ T cells, γδ T cells, monocytes, basophils and eosinophils. Binding of the CD244 ligand, CD48, results in NK cell activation, unlike mouse CD244, which is an inhibitory receptor. For CD244 expressed on NK cells, binding of CD48 results in enhanced NK cell cytotoxicity and secretion of IFN-γ. Recently, it was demonstrated that binding of the C1.7 monoclonal antibody and CD48 involve the same residue in the V domain of human CD244, which explains the ability of C1.7 binding to induce activation of NK cells. Binding of C1.7 to CD244 leads to tyrosine phosphorylation and recruitment of the adaptor molecule SAP (SLAM-associated protein). Patients with X-linked lymphoproliferative disorder (XLPD) have a mutation in SAP which renders it unable to bind to phosphorylated CD244.
Specifications

Specifications

CD244
eBioC1.7 (C1.7)
Biotin
Conjugated
Murine
100μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
2B4, p38, SLAMF4
IgG1
RUO
Primary
Human