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CD244 Mouse anti-Human, APC, Clone: eBioDM244, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5837-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15538146

  • £189.00 / 100 tests

Estimated Shipment: 28-09-2021

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Description

Description

Description: The eBioDM244 monoclonal antibody reacts with human CD244 (2B4, p38). In human, CD244 is a 38 kDa protein expressed on NK cells, a subset of CD8+ T cells, gammadelta T cells, monocytes, basophils and eosinophils. Binding of the CD244 ligand, CD48, results in NK cell activation, unlike mouse CD244, which is an inhibitory receptor. Applications Reported: This eBioDM244 antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBioDM244 antibody has been pre-titrated and tested by flow cytonetric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
Specifications

Specifications

CD244
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q9BZW8
2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
eBioDM244
APC
CD244
Liquid
CD244
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
51744
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For Research Use Only.