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CD244.1 Rat anti-Mouse, PerCP-eFluor 710, Clone: C9.1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-2440-80

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15529226

  • £91.11 / 25µg


Estimated Shipment date
from Supplier 01-09-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody C9.1 reacts with mouse CD244.1. This receptor is expressed on NK cells, gamma delta T cells, some CD8+ T cells, basophils, and monocytes on most inbred mouse strains except C57BL/6 and C58, which express the CD244.2 allotype. CD244 is a CD2-related receptor belonging to the SLAM family that exists as two different isoforms with opposing functions. CD244 associates with CD48, which is expressed widely on hematopoietic cells, regulates NK cell proliferation, cytotoxicity, and cytokine production. However, the CD244/CD28 interaction between NK and other cell types inhibits NK cytotoxicity, which contributes to self-tolerance. CD244 may enhance or inhibit CD8+ T cell effector function depending on SAP levels.

The C9.1 antibody has been reported to have antagonist activity on activated NK cells.
Description & Specifications

Specifications

CD244.1
C9.1
PerCP-eFluor 710
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
2B4, SLAMF4, NK cell type I receptor protein
IgG2b
RUO
Primary
Murine