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CD244.1 Rat anti-Mouse, APC, Clone: C9.1, eBioscience™

Rat Monoclonal Antibody

£88.00 - £203.00

Specifications

Antigen CD244.1
Clone C9.1
Target Species Mouse
Conjugate APC
Isotype IgG2b, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15538066
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Affymetrix eBioscience
17-2440-80
25 μg
£88.00
25µg
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Estimated Shipment: 29-11-2021
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15548066
View Documents
Affymetrix eBioscience
17-2440-82
100 μg
£203.00
100µg
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Save Up to 
»
Estimated Shipment: 29-11-2021
Please to purchase this item. Need a web account? Register with us today!
Description

Description

Description: The monoclonal antibody C9.1 reacts with mouse CD244.1. This receptor is expressed on NK cells, gamma delta T cells, some CD8+ T cells, basophils, and monocytes on most inbred mouse strains except C57BL/6 and C58, which express the CD244.2 allotype. CD244 is a CD2-related receptor belonging to the SLAM family that exists as two different isoforms with opposing functions. CD244 associates with CD48, which is expressed widely on hematopoietic cells, regulates NK cell proliferation, cytotoxicity, and cytokine production. However, the CD244/CD28 interaction between NK and other cell types inhibits NK cytotoxicity, which contributes to self-tolerance. CD244 may enhance or inhibit CD8+ T cell effector function depending on SAP levels. The C9.1 antibody has been reported to have antagonist activity on activated NK cells. Applications Reported: This C9.1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This C9.1 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.

Filtration: 0.2 μm post-manufacturing filtered. This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

CD244.1
Mouse
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
C9.1
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO
SDS
Product Certifications

For Research Use Only.