CD243 (ABCB1) Mouse anti-Human, PE, Clone: UIC2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-2439-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15576946

Quantity Price
1 £ 182.82 / 100 tests
Estimated Shipment date
from Supplier 05-05-2017
Add to basket


Description and Specification

Specification

Host Species Murine
Quantity 100 Tests
Format Conjugated
Gene Alias P-glycoprotein-1, MDR1
Conjugate PE
Isotype IgG2a
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.5μg)/test
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Regulatory Status RUO
Antigen CD243 (ABCB1)
Clone UIC2
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human

This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes.

This antibody has been reported to inhibit MDR1-mediated efflux.