CD243 (ABCB1) Mouse anti-Human, PE, Clone: UIC2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-2439-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15566946

Quantity Price
1 £ 78.88 / 25 tests
EU Stock 1
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Description and Specification

Specification

Gene Alias P-glycoprotein-1, MDR1
Species Reactivity Human
Concentration 5μL (0.5μg)/test
Quantity 25 tests
Isotype IgG2a
Applications Flow Cytometry
Antigen CD243 (ABCB1)
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Primary or Secondary Primary
Conjugate PE
Clone UIC2
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Host Species Mouse

This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes.

This antibody has been reported to inhibit MDR1-mediated efflux.