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CD243 (ABCB1) Mouse anti-Human, FITC, Clone: UIC2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-2439-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15586516

  • £72.48 / 25 tests


Estimated Shipment date
from Supplier 27-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes.

This antibody has been reported to inhibit MDR1-mediated efflux.
Description & Specifications

Specifications

CD243 (ABCB1)
UIC2
FITC
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.5μg)/test
Conjugated
P-glycoprotein-1, MDR1
IgG2a
RUO
Primary
Human