CD243 (ABCB1) Mouse anti-Human, FITC, Clone: UIC2, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-2439-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg

Disclaimers: For Research Use Only.

Product Code. 15586516

Quantity Price
1 £ 72.48 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification


Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Species Reactivity Human
Antigen CD243 (ABCB1)
Conjugate FITC
Applications Flow Cytometry
Isotype IgG2a
Concentration 5μL (0.5μg)/test
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone UIC2
Quantity 25 tests
Primary or Secondary Primary
Gene Alias P-glycoprotein-1, MDR1
Format Conjugated

This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes.

This antibody has been reported to inhibit MDR1-mediated efflux.