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CD243 (ABCB1), FITC, clone: UIC2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-2439-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15586516

  • £74.99 / 25 tests


Estimated Shipment date
from Supplier 02-07-2018
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Description

Description

Description: This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170-kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes.This antibody has been reported to inhibit MDR1-mediated efflux.Applications Reported: This UIC2 antibody has been reported for use in flow cytometric analysis.Applications Tested: This UIC2 antibody has been pre-titrated and tested by flow cytometric analysis on multidrug resistant cell lines. This can be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD243 (ABCB1)
Monoclonal
5μl/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P08183
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance, multidrug resistance protein 1, CD243
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
UIC2
FITC
ABCB1
Conjugated
ABCB1
IgG2a, kappa
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
5243
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