CD230 (PrP) Mouse anti-Human, Clone: 4D5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9230-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15208167

Quantity Price
1 £ 97.22 / 100µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Species Reactivity Human
Gene Alias Prion protein
Regulatory Status RUO
Clone 4D5
Applications Flow Cytometry
Applications Immunoprecipitation
Applications Western Blotting
Isotype IgG1
Quantity 100μg
Storage Requirements Store at 2-8°C.
Antigen CD230 (PrP)
Host Species Mouse
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Purified

CD230 (prion protein; PrPC) is a 35 kD glycoprotein, attached to the cell surface via a GPI-anchor. While the function of CD230 is unclear, prion protein has been the focus of research based on its involvement in transmissible spongiform encephalopathies (TSE), including Creutzfeld-Jakob disease in humans. CD230 undergoes a conformational change in which the cellular PrPC form is converted to the scrapie PrPSc form. This conversion is essential for the infectiousness of prion-based diseases. CD230 is predominantly expressed on the surface of lymphocytes and monocytes, with weak expression on granulocytes and erythrocytes. In platelets, CD230 is expressed primarily intracellularly, and is upregulated to the surface upon activation.