CD230 (PrP) Mouse anti-Human, Clone: 4D5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9230-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15298157

Quantity Price
1 £ 54.42 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Clone 4D5
Host Species Mouse
Conjugate Unlabeled
Applications Flow Cytometry
Applications Immunoprecipitation
Applications Western Blotting
Species Reactivity Human
Primary or Secondary Primary
Antigen CD230 (PrP)
Gene Alias Prion protein
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Quantity 25μg
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG1
Format Purified

CD230 (prion protein; PrPC) is a 35 kD glycoprotein, attached to the cell surface via a GPI-anchor. While the function of CD230 is unclear, prion protein has been the focus of research based on its involvement in transmissible spongiform encephalopathies (TSE), including Creutzfeld-Jakob disease in humans. CD230 undergoes a conformational change in which the cellular PrPC form is converted to the scrapie PrPSc form. This conversion is essential for the infectiousness of prion-based diseases. CD230 is predominantly expressed on the surface of lymphocytes and monocytes, with weak expression on granulocytes and erythrocytes. In platelets, CD230 is expressed primarily intracellularly, and is upregulated to the surface upon activation.