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CD227 (Mucin 1) Monoclonal Antibody (SM3), eFluor™ 615, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 42-9893-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15321130

  • £168.00 / 25µg
Estimated Shipment: 07-05-2024
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Description

Description

Description: This SM3 monoclonal antibody reacts with the under-glycosylated form of human Mucin 1 (MUC1, CD227), a large glycoprotein belonging to the mucin protein family. Mucin 1 contains a polypeptide core consisting of multiple tandem repeats that become highly glycosylated. Mucin 1 is typically expressed in ductal or glandular epithelial cells and is localized to the apical membrane. In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. High levels of under-glycosylated Mucin 1 are thought to affect cell behavior during both invasion and metastasis as well as in immune recognition. In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. Alterations in Mucin 1 glycosylation are found in most adenocarcinomas of the breast, lung, pancreas, prostate, and ovary. Mucin 1 has recently been shown to co-localize and interact with members of the erbB receptor kinase family, proteins that are upregulated in more aggressive forms of breast cancer. Please note this antibody sees a distinct epitope from other Mucin 1 antibodies. Applications Reported: This SM3 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections (IHC-P) and immunocytochemistry (ICC).

CD227 (Mucin 1) Monoclonal antibody specifically detects CD227 (Mucin 1) in Human samples. It is validated for Immunocytochemistry, Immunohistochemistry (Paraffin).
Specifications

Specifications

CD227 (Mucin 1)
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P15941
MUC1
Affinity chromatography
RUO
4582
4° C, store in dark, DO NOT FREEZE!
Liquid
Immunocytochemistry, Immunohistochemistry (Paraffin)
SM3
eFluor 615
MUC1
ADMCKD; ADMCKD1; Breast carcinoma-associated antigen DF3; CA 15-3; Cancer antigen 15-3; carcinoma-associated mucin; CD227; DF3 antigen; EMA; Episialin; H23 antigen; H23AG; J19; KL-6; Krebs von den Lungen-6; MAM6; MCD; MCKD; MCKD1; Medullary cystic kidney disease, autosomal dominant; Muc1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; MUC1-alpha; MUC1-beta; MUC1-CT; MUC1-NT; mucin 1, cell surface associated; mucin 1, transmembrane; Mucin1; mucin-1; Mucin-1 subunit alpha; Mucin-1 subunit beta; peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen; Tumor-associated mucin
Mouse
25 μg
Primary
Human
Antibody
IgG1
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For Research Use Only.