CD227 (Mucin-1) Mouse anti-Human, eFluor 615, Clone: SM3, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 42-9893-82


UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg

Disclaimers: For Research Use Only.

Product Code. 15331130

Quantity Price
1 £232.00 / 100µg
Estimated Shipment date
from Supplier 28-10-2016
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Description and Specification


Antigen CD227 (Mucin-1)
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Clone SM3
Concentration 0.2mg/mL
Conjugate eFluor 615
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Mucin Glycoprotein, MUC1, EMA (Epithelial Membrane Antigen), Episialin, Tumor-Associated Mucin, PEM (Polymorphic Epithelial Mucin), Breast Cancer-Associated Antigen
Host Species Mouse
Isotype IgG1
Quantity 100μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

This SM3 monoclonal antibody reacts with the under-glycosylated form of human Mucin 1 (MUC1, CD227), a large glycoprotein belonging to the mucin protein family. Mucin 1 contains a polypeptide core consisting of multiple tandem repeats that become highly glycosylated. Mucin 1 is typically expressed in ductal or glandular epithelial cells and is localized to the apical membrane. In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. High levels of under-glycosylated Mucin 1 are thought to affect cell behavior during both invasion and metastasis as well as in immune recognition. In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. Alterations in Mucin 1 glycosylation are found in most adenocarcinomas of the breast, lung, pancreas, prostate, and ovary. Mucin 1 has recently been shown to co-localize and interact with members of the erbB receptor kinase family, proteins that are upregulated in more aggressive forms of breast cancer.
Please note this antibody sees a distinct epitope from other Mucin 1 antibodies.