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CD227 (Mucin 1) Monoclonal Antibody (SM3), Alexa Fluor™ 488, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£168.00 - £414.00

Specifications

Antigen CD227 (Mucin 1)
Clone SM3
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15362090
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Affymetrix eBioscience
53-9893-80
25 μg
£168.00
25µg
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Estimated Shipment: 07-05-2024
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15372090
View Documents Promotion Details
Affymetrix eBioscience
53-9893-82
100 μg
£414.00
100µg
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Estimated Shipment: 08-04-2024
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Description

Description

Description: This SM3 monoclonal antibody reacts with the under-glycosylated form of human Mucin 1 (MUC1, CD227), a large glycoprotein belonging to the mucin protein family. Mucin 1 contains a polypeptide core consisting of multiple tandem repeats that become highly glycosylated. Mucin 1 is typically expressed in ductal or glandular epithelial cells and is localized to the apical membrane. In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. High levels of under-glycosylated Mucin 1 are thought to affect cell behavior during both invasion and metastasis as well as in immune recognition. In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. Alterations in Mucin 1 glycosylation are found in most adenocarcinomas of the breast, lung, pancreas, prostate, and ovary. Mucin 1 has recently been shown to co-localize and interact with members of the erbB receptor kinase family, proteins that are upregulated in more aggressive forms of breast cancer. Please note this antibody sees a distinct epitope from other Mucin 1 antibodies. Applications Reported: This SM3 antibody has been reported for use in flow cytometric analysis and immunocytochemistry. Applications Tested: This SM3 antibody has been tested by flow cytometry and can be used at less than or equal to 1 μg/mL.

CD227 (Mucin 1) Monoclonal antibody specifically detects CD227 (Mucin 1) in Human samples. It is validated for Flow Cytometry, Immunocytochemistry.
Specifications

Specifications

CD227 (Mucin 1)
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
ADMCKD; ADMCKD1; Breast carcinoma-associated antigen DF3; CA 15-3; Cancer antigen 15-3; carcinoma-associated mucin; CD227; DF3 antigen; EMA; Episialin; H23 antigen; H23AG; J19; KL-6; Krebs von den Lungen-6; MAM6; MCD; MCKD; MCKD1; Medullary cystic kidney disease, autosomal dominant; Muc1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; MUC1-alpha; MUC1-beta; MUC1-CT; MUC1-NT; mucin 1, cell surface associated; mucin 1, transmembrane; Mucin1; mucin-1; Mucin-1 subunit alpha; Mucin-1 subunit beta; peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen; Tumor-associated mucin
MUC1
Primary
4° C, store in dark, DO NOT FREEZE!
MUC1
SM3
Flow Cytometry, Immunocytochemistry
Alexa Fluor 488
Mouse
Human
P15941
4582
IgG1
Affinity chromatography
Antibody
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