CD221 (Insulin-like Growth Factor-1 Receptor) Mouse anti-Human, APC, Clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-8849-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15568206

Quantity Price
1 £ 158.36 / 100 tests
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Primary or Secondary Primary
Quantity 100 tests
Clone 1H7
Antigen CD221 (Insulin-like Growth Factor-1 Receptor)
Format Conjugated
Applications Flow Cytometry
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate APC
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test
Monoclonal or Polyclonal Monoclonal
Isotype IgG1
Gene Alias IGF-1R
Species Reactivity Human

This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.

This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.