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CD221 (IGF1R), APC, clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-8849-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15568206

  • £162.21 / 100 tests


Estimated Shipment date
from Supplier 03-07-2018
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Description

Description

Description: This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.Applications Reported: This 1H7 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 1H7 antibody has been pre-titrated and tested by flow cytometric analysis of the HeLa cell line. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD221 (Insulin-like Growth Factor-1 Receptor)
Monoclonal
5μl/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P08069
IGF-1R
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
1H7
APC
IGF1R
Conjugated
IGF1R
IgG1, kappa
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
3480
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