CD221 (Insulin-like Growth Factor-1 Receptor) Mouse anti-Human, Alexa Fluor 488, Clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-8849-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15590257

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 02-06-2017
Add to basket


Description and Specification

Specification

Antigen CD221 (Insulin-like Growth Factor-1 Receptor)
Applications Flow Cytometry
Clone 1H7
Concentration 5μL (0.5μg)/test
Conjugate Alexa Fluor 488
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias IGF1R
Host Species Murine
Isotype IgG1
Quantity 25 Tests
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human

This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.

This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.