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CD221 (Insulin-like Growth Factor-1 Receptor) Mouse anti-Human, Alexa Fluor 488, Clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-8849-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15500267

  • £158.36 / 100 tests


EU Stock 4
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Disclaimers:

For Research Use Only.


Description

Description

This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.

This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.
Specifications

Specifications

CD221 (Insulin-like Growth Factor-1 Receptor)
1H7
Alexa Fluor™ 488
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IGF1R
IgG1
RUO
Primary
Human