CD221 (Insulin-like Growth Factor-1 Receptor) Mouse anti-Human, Alexa Fluor 488, Clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-8849-42

100TEST Anti-Human CD221 (Insulin-like Growth Factor-1 Receptor) Alexa Fluor 488

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15500267

Quantity Price
1 £ 241.3 / 100 tests
Estimated Shipment date
from Supplier 23-01-2017
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Description and Specification

Specification

Antigen CD221 (Insulin-like Growth Factor-1 Receptor)
Applications Flow Cytometry
Clone 1H7
Concentration 5μL (0.5μg)/test
Conjugate Alexa Fluor 488
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias IGF1R
Host Species Mouse
Isotype IgG1
Quantity 100 tests
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.

This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.