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CD22 Mouse anti-Human, APC, Clone: S-HCL-1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-4229-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15518096

  • £158.36 / 100 tests


Estimated Shipment date
from Supplier 27-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The S-HCl-1 monoclonal antibody recognizes human CD22 (Siglec-2), which is a member of the siglec subgroup of the Ig superfamily. CD22 is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22a and CD22ß, of 130 and 140kDa respectively, produced by alternative splicing of the CD22 gene. CD22 is expressed at high levels on mature B cells and B cell lymphomas. The extracellular portion of CD22 contains seven Ig-like domains, some of which are capable of binding ligands with sialic acid moieties expressed on epithelial, endothelial, B and T cells. The intracellular portion of CD22 contains 6 tyrosine residues contained within immunotyrosine-based inhibitory motifs (ITIM) and immunotyrosine-based activation-like motifs, which are phosphorylated upon B-cell receptor engagement, which enables CD22 to participate in the positive and negative regulation of B-cell receptor signaling.
Description & Specifications

Specifications

CD22
S-HCL-1
Allophycocyanin
aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
Conjugated
siglec2, siglec 2
IgG2b
RUO
Primary
Human