CD22 Mouse anti-Human, APC, Clone: S-HCL-1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-4229-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15518096

Quantity Price
1 £ 158.36 / 100 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Human
Format Conjugated
Quantity 100 tests
Host Species Mouse
Concentration 5μL (0.125μg)/test
Isotype IgG2b
Clone S-HCL-1
Gene Alias siglec2, siglec 2
Antigen CD22
Conjugate APC

The S-HCl-1 monoclonal antibody recognizes human CD22 (Siglec-2), which is a member of the siglec subgroup of the Ig superfamily. CD22 is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22a and CD22ß, of 130 and 140kDa respectively, produced by alternative splicing of the CD22 gene. CD22 is expressed at high levels on mature B cells and B cell lymphomas. The extracellular portion of CD22 contains seven Ig-like domains, some of which are capable of binding ligands with sialic acid moieties expressed on epithelial, endothelial, B and T cells. The intracellular portion of CD22 contains 6 tyrosine residues contained within immunotyrosine-based inhibitory motifs (ITIM) and immunotyrosine-based activation-like motifs, which are phosphorylated upon B-cell receptor engagement, which enables CD22 to participate in the positive and negative regulation of B-cell receptor signaling.