CD217 (IL-17Ra), Functional Grade, clone: 424LTS, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 16-7917-85
Code : Z2
Additional Details : Weight : 0.01000kg
DescriptionDescription: The 424LTS monoclonal antibody reacts with and blocks IL-17A binding to human interleukin 17 receptor A (IL-17RA, IL-17R). IL-17RA is a type I membrane protein of approximately 96kDa (866 amino acids) and is involved in inflammatory responses to IL-17A, IL-17F and IL-17AF heterodimer. It forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling. IL-17RA is ubiquitously expressed, but in leukocytes its expression is elevated on granulocytes and monocytes.Applications Reported: This 424LTS antibody has been reported for use in blocking IL-17 receptor A ligand binding.Applications Tested: The ND50 of 424LTS as measured by the inhibition of IL-6 induction in NHDF cells is 1-5μg/ml in the presence of 3 ng/ml of recombinant Human IL-17A. Neutralization dose will vary depending on assay method, cytokine concentration, and cell type. This antibody should be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
|CD217 (IL-17 Receptor A)|
|PBS with no preservative; pH 7.2|
|interleukin 17 receptor A, AW538159, Cdw217, IL17r, VDw217, interleukin 17 receptor|
|Store at 2-8°C.|
For Research Use Only.