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CD217 (IL-17Ra), Functional Grade, clone: 424LTS, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-7917-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15218817

  • £218.73 / 500µg


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Description

Description

Description: The 424LTS monoclonal antibody reacts with and blocks IL-17A binding to human interleukin 17 receptor A (IL-17RA, IL-17R). IL-17RA is a type I membrane protein of approximately 96kDa (866 amino acids) and is involved in inflammatory responses to IL-17A, IL-17F and IL-17AF heterodimer. It forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling. IL-17RA is ubiquitously expressed, but in leukocytes its expression is elevated on granulocytes and monocytes.Applications Reported: This 424LTS antibody has been reported for use in blocking IL-17 receptor A ligand binding.Applications Tested: The ND50 of 424LTS as measured by the inhibition of IL-6 induction in NHDF cells is 1-5μg/ml in the presence of 3 ng/ml of recombinant Human IL-17A. Neutralization dose will vary depending on assay method, cytokine concentration, and cell type. This antibody should be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

CD217 (IL-17 Receptor A)
Monoclonal
1mg/mL
PBS with no preservative; pH 7.2
Q96F46
interleukin 17 receptor A, AW538159, Cdw217, IL17r, VDw217, interleukin 17 receptor
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Functional Assay
424LTS
Functional Grade
IL17RA
Purified
IL17RA
IgG1, kappa
500μg
Store at 2-8°C.
Primary
23765
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