CD215 (IL-15 Receptor alpha) Mouse anti-Human, PE, Clone: eBioJM7A4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-7159-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15507106

Quantity Price
1 £ 182.82 / 100 tests
EU Stock 1
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Gene Alias Interleukin-15 Receptor alpha, IL-15R, IL15R
Isotype IgG2b
Conjugate PE
Species Reactivity Human
Applications Flow Cytometry
Format Conjugated
Quantity 100 tests
Monoclonal or Polyclonal Monoclonal
Antigen CD215 (IL-15 Receptor alpha)
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.125μg)/test
Regulatory Status RUO
Primary or Secondary Primary
Clone eBioJM7A4

The eBioJM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain (IL-15Rα). IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects. Their receptors share 2 subunits, the IL-2Rβ and γ chains, which are essential for signal transduction. The IL-15Rα receptor is structurally related to IL-2Rα. However, the IL-15Rα alone binds IL-15 with a 1,000-fold higher affinity than that seen with IL-2Rα and IL-2. In the human, 3 differentially spliced human IL-15Rα variants that are all capable of high affinity binding of IL-15 have been isolated. The cytoplasmic domain of IL-15Rα, like that of IL-2Rα, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL-2Rβ and IL-2Rγ in the absence of the alpha subunit.