CD21/CD35 Rat anti-Mouse, PE, Clone: eBio8D9 (8D9), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-0211-83

200UG ANTI-MOUSE CD21/CD35 PE

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15288479

Quantity Price
1 £ 176.7 / 200µg
Estimated Shipment date
from Supplier 29-03-2017
Add to basket


Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Conjugate PE
Antigen CD21/CD35
Format Conjugated
Gene Alias CR2/CR1, C3DR
Host Species Rat
Applications Flow Cytometry
Isotype IgG2a
Quantity 200μg
Regulatory Status RUO
Species Reactivity Mouse
Primary or Secondary Primary
Clone eBio8D9 (8D9)
Concentration 0.2mg/mL

The monoclonal antibody eBio8D9 reacts with an eptiope shared by mouse CD21 (CR2) and CD35 (CR1). CD21 and CD35 are alternatively spliced transcripts from the Cr2 gene, which produce cell-surface proteins of 145 and 190 kDa, respectively. CD21 and CD35 are expressed by mature B cells, but not on thymocytes, peripheral T cells, erythrocytes or platelets. Furthermore, there is some evidence which demonstrates their expression on macrophages. CD21 is a receptor for the complement component C3d and Epstein-Barr virus (EBV). In association with CD19 and CD81, CD21 also participates in B-cell activation through the B cell receptor. Cr2-deficient mice display impaired inflammatory and humoral immune responses in vivo.

The anti-mouse CD21/35 monoclonal antibody clones eBio4E3 and eBio8D9 do not cross-block each other, suggesting that they bind to different epitopes.