CD209b (SIGN-R1) Armenian Hamster anti-Mouse, Clone: eBio22D1 (22D1), eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-2093-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15217317

Quantity Price
1 £ 78.88 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Concentration 0.5mg/mL
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Enzyme Linked Immunosorbent Assay
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Species Reactivity Mouse
Primary or Secondary Primary
Gene Alias C-type lectin, SIGNR1
Isotype IgG
Clone eBio22D1 (22D1)
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Host Species Armenian Hamster
Format Purified
Quantity 100μg
Antigen CD209b (SIGN-R1)

The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b). SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase. The eBio22D1 monoclonal antibody does not cross-react with the closely related SIGNR1, SIGNR2, SIGNR3 or SIGNR4.