CD209b (SIGN-R1) Armenian Hamster anti-Mouse, APC, Clone: 22D1, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-2093-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg

Disclaimers: For Research Use Only.

Product Code. 15330710

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification


Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Species Reactivity Mouse
Gene Alias C-type lectin
Isotype IgG
Conjugate APC
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Armenian Hamster
Quantity 25μg
Clone 22D1
Applications Flow Cytometry
Primary or Secondary Primary
Antigen CD209b (SIGN-R1)
Concentration 0.2mg/mL
Format Conjugated
Regulatory Status RUO

The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b). SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase. The eBio22D1 monoclonal antibody does not cross-react with the closely related SIGNR1, SIGNR2, SIGNR3 or SIGNR4.