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CD207 (Langerin) Rat anti-Mouse, Clone: eBioL31, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-2075-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15247307

  • £54.42 / 25µg


Estimated Shipment
30-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The eBioL31 monoclonal antibody reacts with mouse CD207, also known as Langerin, which is expressed in a distinct subset of dendritic cells called Langerhans cells (LC). Mouse CD207 is a 48kDa C-type lectin transmembrane protein that likely plays a role in antigen recognition and uptake. LC are located in the epidermis and upon activation, reduce CD207 expression and begin migrating through the dermis towards lymphatic vessels. Expression of mouse CD207 in LC has been correlated to the presence of Birbeck Granules. Furthermore, the formation of Birbeck Granules has been observed upon transfection of CD207 cDNA into fibroblast cell lines.

Western Blotting with eBioL31 reveals a 48kDa band in lysate from mouse ear epidermis, as well as in lysates from cells transfected with mouse CD207 cDNA. Preliminary data from mouse CD207 cDNA transfected cells suggests that eBioL31 can be used for intracellular flow cytometric analysis in combination with the Foxp3/Transcription Factor Staining Bufer Set (cat. 00-5523). The epitope recognized by eBioL31 is in the extracellular domain within the CRD (carbohydrate recognition domain) and therefore can be used to detect both surface and intracellular langerin. Differences in expression has been observed between mouse strains.
Specifications

Specifications

CD207 (Langerin)
eBioL31
Unconjugated
Purified
Rat
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clec4K
IgG2a
RUO
Primary
Murine