CD201 (EPCR) Rat anti-Mouse, Biotin, Clone: eBio1560 (1560), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-2012-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15239769

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Clone eBio1560 (1560)
Storage Requirements Store at 2-8°C. Do not freeze.
Antigen CD201 (EPCR)
Species Reactivity Mouse
Applications Flow Cytometry
Applications Immunohistochemistry
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Concentration 0.5mg/mL
Gene Alias Endothelial Protein C Receptor
Isotype IgG2b
Format Conjugated
Primary or Secondary Primary
Conjugate Biotin
Host Species Rat
Quantity 25μg

The eBio1560 monoclonal antibody reacts with mouse Endothelial Protein C Receptor (EPCR, CD201), a 25kDa Type 1 transmembrane protein expressed on endothelial cells. EPCR exhibits sequence and structural homology with the MHC class I/CD1 family of proteins. EPCR is a ligand for Protein C and plays an important role in augmenting Protein C activation by the thrombin-thrombomodulin complex and in regulating blood coagulation and inflammation. Deletion of EPCR results in embryonic lethality, at least partically due to placental thrombosis.

Recently, it was demonstrated that EPCR expression identified cells in the bone marrow that are capable of hematopoietic reconstitution activity comparable to hematopoietic stem cells isolated with conventional methods. The eBio1560 monoclonal antibody can be used for the detection of these hematopoietic stem cells, however the eBiomRCR-16 monoclonal antibody should only be used for the detection of CD201 on endothelial cells.