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CD201 (EPCR) Rat anti-Human, APC, Clone: RCR-227, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-2018-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15508056

  • £164.47 / 100 tests


Estimated Shipment date
from Supplier 25-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody RCR-227 reacts with human CD201, which is also known as the endothelial protein C receptor (EPCR), a 46kDa transmembrane protein related to class I MHC. CD201 was originally identified on vascular endothelium cells, predominantly larger blood vessels. It is also expressed on monocytes, lymphocytes, hematopoietic stem cells, neutrophils, and eosinophils. CD201 serves as a binding site for protein C, activated protein C (APC), and factor VII/VIIa. A soluble form has also been identified in the plasma. CD201 plays a role in controlling coagulation as disruption of its gene in mice caused placental thrombosis and early embryonic death. This cell surface molecule is also involved in the anti-inflammatory response. APC binding to CD201 enables PAR-1 activation that confers cytoprotective effects. In monocytes, APC binding decreases secretion of proinflammatory cytokines, chemokines, and growth factors. Finally, CD201 has been shown to inhibit lymphocyte migration.
Specifications

Specifications

CD201 (EPCR)
RCR-227
Allophycocyanin
Conjugated
Rat
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Endothelial protein C receptor
IgG1
RUO
Primary
Human