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CD201 (EPCR), APC, clone: RCR-227, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-2018-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15598046

  • £62.12 / 25 tests


Estimated Shipment date
from Supplier 22-02-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: The monoclonal antibody RCR-227 reacts with human CD201, which is also known as the endothelial protein C receptor (EPCR), a 46-kDa transmembrane protein related to class I MHC. CD201 was originally identified on vascular endothelium cells, predominantly larger blood vessels. It is also expressed on monocytes, lymphocytes, hematopoietic stem cells, neutrophils, and eosinophils. CD201 serves as a binding site for protein C, activated protein C (APC), and factor VII/VIIa. A soluble form has also been identified in the plasma. CD201 plays a role in controlling coagulation as disruption of its gene in mice caused placental thrombosis and early embryonic death. This cell surface molecule is also involved in the anti-inflammatory response. APC binding to CD201 enables PAR-1 activation that confers cytoprotective effects. In monocytes, APC binding decreases secretion of proinflammatory cytokines, chemokines, and growth factors. Finally, CD201 has been shown to inhibit lymphocyte migration.Applications Reported: This RCR-227 antibody has been reported for use in flow cytometric analysis.Applications Tested: This RCR-227 antibody has been pre-titrated and tested by flow cytometric analysis of HUVECs. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD201 (EPCR)
RCR-227
APC
Conjugated
Rat
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Endothelial protein C receptor
IgG1
RUO
Primary
Human
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